Published May 2005 | Version v1
Journal article Metadata-only

Magnetizable implants and functionalized magnetic carriers: A novel approach for noninvasive yet targeted drug delivery

Creators

  • 1. Departments of Neurology and Surgery (Neurosurgery), University of Chicago and Pritzker School of Medicine, 5841 South Maryland Ave, MC 2030, Chicago, IL 60637 (United States)
  • 2. Chemical Engineering Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, IL 60439 (United States)
  • 3. Department of Chemical Engineering, Swearingen Engineering Center, University of South Carolina, Columbia, SC 29208 (United States)

Description

We describe a targeted drug delivery system consisting of two steps: first, intravenous injection and circulation of biocompatible, magnetic nanospheres encapsulated with a drug; and second, focal concentration and release of the drug at the target site utilizing an implanted, magnetizable intraluminal stent or seed. We introduce the system concept, outline the biomedical feasibility, and discuss potential clinical advantages

Additional details

Identifiers

DOI
10.1016/j.jmmm.2005.01.087;
PII
S0304-8853(05)00145-9;

Publishing Information

Journal Title
Journal of Magnetism and Magnetic Materials
Journal Volume
293
Journal Issue
1
Journal Page Range
p. 633-638
ISSN
0304-8853
CODEN
JMMMDC

Conference

Title
5. International conference on scientific and clinical applications of magnetic carriers
Dates
20-22 May 2004
Place
Lyon (France)

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
37029357
Subject category
S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CARRIERS; DRUGS; IMPLANTS; INTRAVENOUS INJECTION; MAGNETIC MATERIALS; THERAPEUTIC USES
Descriptors DEC
INJECTION; INTAKE; MATERIALS; USES

Optional Information

Copyright
Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.