Published July 25, 2013 | Version v1
Journal article Metadata-only

Role of Hydroxamate-Based Histone Deacetylase Inhibitors (Hb-HDACIs) in the Treatment of Solid Malignancies

Creators

  • 1. Department of Experimental and Clinical Sciences, University 'G. d'Annunzio', I-66013 Chieti (Italy)
  • 2. Hospital Pharmacy, "SS. Annunziata" Hospital, I-66013 Chieti (Italy)
  • 3. Oncology Department, "SS. Annunziata" Hospital, I-66013 Chieti (Italy)

Description

Hydroxamate-based histone deacetylase inhibitors (Hb-HDACIs), such as vorinostat, belinostat and panobinostat, have been previously shown to have a wide range of activity in hematologic malignancies such as cutaneous T-cell lymphoma and multiple myeloma. Recent data show that they synergize with a variety of cytotoxic and molecular targeted agents in many different solid tumors, including breast, prostate, pancreatic, lung and ovarian cancer. Hb-HDACIs have a quite good toxicity profile and are now being tested in phase I and II clinical trials in solid tumors with promising results in selected neoplasms, such as hepatocarcinoma. This review will focus on their clinical activity and safety in patients with advanced solid neoplasms

Availability note (English)

Available from http://dx.doi.org/10.3390/cancers5030919; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795372

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795372;
DOI
10.3390/cancers5030919;

Publishing Information

Journal Title
Cancers (Basel)
Journal Volume
5
Journal Issue
3
Journal Page Range
p. 919-942
ISSN
2072-6694

INIS

Country of Publication
Switzerland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
47001843
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CLINICAL TRIALS; MAMMARY GLANDS; NEOPLASMS; SOLIDS
Descriptors DEC
BODY; DISEASES; GLANDS; ORGANS; TESTING

Optional Information

Copyright
Copyright (c) 2013 by the authors
Notes
PMCID: PMC3795372; PMID: 24202327; PUBLISHER-ID: cancers-05-00919; OAI: oai:pubmedcentral.nih.gov:3795372; licensee MDPI, Basel, Switzerland.; This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).