Advancement of electroosmotic pump in microflow analysis: A review

Highlights: • Surveyed literature on EOP progress in the past ten years. • Updated information on high-pressure EOP. • Updated information on low-field EOP. • Emphasized EOP applications. • Discussed characteristics, pros and cons and development directions of EOP. -- Abstract: This review (with 152 references) covers the progress made in the development and application of electroosmotic pumps in a period from 2009 through 2018 in microflow analysis. Following a short introduction, the review first categorizes various electroosmotic pumps into five subclasses based on the materials used for pumping: i) open channel EOP, 2) packed-column EOP, iii) porous monolith EOP, iv) porous membrane EOP, and v) other types of EOP. Pumps in each subclass are discussed. A next section covers EOP applications, primarily the applications of EOPs in micro flow analysis and micro/nano liquid chromatography. Other scattered applications are also examined. Perspectives, trends and challenges are discussed in the final section.