Published March 1977
| Version v1
Journal article
Glycolytic changes in x-irradiated rats
Creators
- 1. Bhabha Atomic Research Centre, Bombay (India). Biochemistry and Food Technology Div.
Description
Whole-body exposure of rat to lethal dose (800 rad) of X-irradiation alters the relationship between oxidized and reduced metabolites of NAD+-linked lactate dehydrogenase, namely, lactate and pyruvate in the tissues. This, in turn, affects the redox state of NAD+. Endogenous oxygen consumption in liver decreases significantly in X-irradiated rat liver after 5 days; addition of pyruvate does not show any effect on oxygen uptake. A reduction in the activity of liver glutamine-keto acid aminotransferase EC (2.6.1.15) activity further indicates impairment in pyruvate metabolism due to radiation treatment. (author)
Additional details
Publishing Information
- Journal Title
- Indian J. Biochem. Biophys.
- Journal Volume
- 14
- Journal Issue
- 1
- Series
- Indian J. Biochem. Biophys.
- Journal Page Range
- 56-58
INIS
- Country of Publication
- India
- Country of Input or Organization
- India
- INIS RN
- 8334850
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- AMINOTRANSFERASES; BIOLOGICAL RADIATION EFFECTS; GLYCOLYSIS; HOMOGENATES; IN VITRO; LACTATE DEHYDROGENASE; LACTIC ACID; LETHAL IRRADIATION; LIVER; METABOLISM; PYRUVIC ACID; RATS; SUBSTRATES; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DECOMPOSITION; DEHYDROGENASES; DIGESTIVE SYSTEM; ENZYMES; EXTERNAL IRRADIATION; GLANDS; HYDROXY ACIDS; IRRADIATION; KETO ACIDS; MAMMALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; OXIDOREDUCTASES; RADIATION EFFECTS; RODENTS; TRANSFERASES; VERTEBRATES
Optional Information
- Notes
- 16 refs.