Published December 2018 | Version v1
Journal article Metadata-only

Role of intensive nutrition support and prophylactic percutaneous endoscopic gastrostomy during concomitant chemoradiotherapy for oropharyngeal cancer

Creators

  • 1. Kobe University Hospital, Department of Rehabilitation (Japan)
  • 2. Kobe University Graduate School of Health Sciences, Division of Nutrition and Metabolism (Japan)
  • 3. Kobe University Hospital, Department of Otolaryngology-Head and Neck Surgery (Japan)
  • 4. Kobe University Hospital, Department of Medical Oncology and Hematology (Japan)
  • 5. Kobe University Hospital, Department of Radiation Oncology (Japan)

Description

Background

Concomitant chemoradiotherapy (CCRT) produces severe mucositis and swallowing dysfunction, often resulting in malnutrition. Intensive nutrition support (INS) in addition to percutaneous endoscopic gastrostomy (PEG) is reported to decrease adverse effects during CCRT.

Patients and Methods

Fifty-eight patients with oropharyngeal cancer treated by CDDP-based CCRT were retrospectively analyzed. Twenty-nine patients treated with INS in addition to PEG were classified as INS group, and other 29 patients treated with PEG but without INS were classified as control group.

Results

INS in addition to PEG significantly increased calorie intake in the second half of CCRT and reduced adverse events including mucositis (p = 0.0019), leukopenia (p = 0.04), and renal function (p = 0.006). Moreover, 21 out of 29 patients had successfully administration of 200 mg/m2 or more of CDDP, while only 10 out of 29 patients had enough amount of CDDP in control group.

Conclusions

These results suggest that INS in addition to prophylactic PEG not only decreases adverse effects but also may potentially improve oncological outcome of the patients with oropharyngeal cancer treated by CCRT.

Additional details

Identifiers

DOI
10.1007/s10147-018-1328-x;

Publishing Information

Journal Title
International Journal of Clinical Oncology
Journal Volume
23
Journal Issue
6
Journal Page Range
p. 1023-1028
ISSN
1341-9625

INIS

Country of Publication
Japan
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54118559
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
COMBINED THERAPY; INTAKE; KIDNEYS; LEUKOPENIA; NEOPLASMS; NUTRITIONAL DEFICIENCY; PATIENTS
Descriptors DEC
BODY; DISEASES; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; MEDICINE; ORGANS; SYMPTOMS; THERAPY

Optional Information

Copyright
Copyright (c) 2018 The Author(s)