Superoxide dismutase levels in various radioresistant and radiosensitive tissues of irradiated rats
- 1. Karlova Univ., Hradec Kralove (Czechoslovakia). Lekarska Fakulta
Description
The activity of superoxide dismutase (E.C. 1.15.1.1; SOD) was determined in male Wistar rats in order to evaluate the possible relationship between the enzyme content in tissue and the resistance of this tissue to ionizing radiation (8.0 Gy, 60Co). The results showed that some non-irradiated radioresistant organs (liver) had a high SOD activity and on the contrary, in some radiosensitive tissues (bone marrow) the SOD content was low. In spite of this observation it is not possible to generalize the statement that radiosensitivity is directly conditioned by the SOD level without any exception. The SOD content in the spleen was higher than in the brain, but the spleen is remarkably radiosensitive, whereas the brain is not. The radiosensitivity of individual tissues probably reflected the changes in SOD activity after irradiation. (author)
Additional details
Publishing Information
- Journal Title
- Physiol. Bohemoslov.
- Journal Volume
- 31
- Journal Issue
- 2
- Series
- Physiol. Bohemoslov.
- Journal Page Range
- 151-157
- ISSN
- 0369-9463
INIS
- Country of Publication
- Czech Republic
- Country of Input or Organization
- Serbia and Montenegro
- INIS RN
- 13695770
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; BONE MARROW; BRAIN; CATALYSIS; ERYTHROCYTES; GAMMA RADIATION; LIVER; METABOLISM; OXIDOREDUCTASES; RADIATION DOSES; RADIOPROTECTIVE SUBSTANCES; RADIOSENSITIVITY; RATS; SPLEEN; WHOLE-BODY IRRADIATION
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CENTRAL NERVOUS SYSTEM; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; ENZYMES; EXTERNAL IRRADIATION; GLANDS; HEMATOPOIETIC SYSTEM; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RESPONSE MODIFYING FACTORS; RODENTS; TISSUES; VERTEBRATES