Published November 2019
| Version v1
Journal article
Development of a 18F-labeled PET radioligand for imaging 5-HT1B receptors: [18F]AZ10419096
Creators
- 1. Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1003 (United States)
- 2. Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-17176 Stockholm (Sweden)
- 3. PET Science Centre, Precision Medicine and Genomics, R&D, AstraZeneca, SE-17176 Stockholm (Sweden)
- 4. Isotope Chemistry, Early Chemical Development, Pharmaceutical Sciences R&D, AstraZeneca, SE-43250 Göteborg (Sweden)
Description
In the last decade PET has been useful in studying and understanding the 5-HT1B receptor. [11C]AZ10419369 and [11C]P943 have been applied as radioligands in these studies. Both use carbon-11 (t1/2 = 20.4 min) as radionuclide, which limits the application to PET centres that have an on-site cyclotron and radiochemistry facilities. In this paper we report the synthesis and initial evaluation of the first fluorine-18 PET radioligand to image 5-HT1B receptors in brain, [18F]AZ10419096.
Additional details
Identifiers
- DOI
- 10.1016/j.nucmedbio.2019.10.003;
- PII
- S0969805119301726;
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 78
- Journal Page Range
- p. 11-16
- ISSN
- 0969-8051
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55042964
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- BRAIN; CARBON 11; CYCLOTRONS; EVALUATION; FLUORINE 18; IMAGES; POSITRON COMPUTED TOMOGRAPHY; RADIOCHEMISTRY; RECEPTORS; SYNTHESIS
- Descriptors DEC
- ACCELERATORS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBON ISOTOPES; CENTRAL NERVOUS SYSTEM; CHEMISTRY; COMPUTERIZED TOMOGRAPHY; CYCLIC ACCELERATORS; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEMBRANE PROTEINS; MINUTES LIVING RADIOISOTOPES; NANOSECONDS LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; TOMOGRAPHY
Optional Information
- Copyright
- Copyright (c) 2019 Elsevier Inc. All rights reserved.