Chromosomal translocations in accidentally irradiated victims measured by fluorescence in situ hybridization

Translocation aberrations in human peripheral lymphocytes induced by 60Co γ rays were measured using fluorescence in situ hybridization with chromosome 2 probe. A good dose-effect relationship was observed for in vitro exposure. The translocation frequencies in the victims measured at the 6th and 7th year after exposure to 60Co γ rays maintained a relative constancy, which amount to 40%∼50% of dicentrics plus rings frequencies measured immediately after exposure, and the translocation frequencies were well correlated with the original dose