Chemistry for positron emission tomography. Recent advances in ¹¹C-, ¹⁸F-, ¹³N-, and ¹⁵O-labeling reactions

Positron emission tomography (PET) is a molecular imaging technology that provides quantitative information about function and metabolism in biological processes in vivo for disease diagnosis and therapy assessment. The broad application and rapid advances of PET has led to an increased demand for new radiochemical methods to synthesize highly specific molecules bearing positron-emitting radionuclides. This Review provides an overview of commonly used labeling reactions through examples of clinically relevant PET tracers and highlights the most recent developments and breakthroughs over the past decade, with a focus on ¹¹C, ¹⁸F, ¹³N, and ¹⁵O. (copyright 2019 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)