Published January 1988
| Version v1
Journal article
Synthesis of C-9-14C-1,8-dihydroxy-3-carboxyanthraquinone
Creators
- 1. Instituut voor Farmaceutische Wetenschappen, Louvain (Belgium). Lab. voor Farmaceutische Biologie en Fytofarmacologie
Description
The synthesis of C-9-14C-rhein is reported using 14CO2 as a 14C-source. After preparing 14C-1, 8-dimethoxy-3-methylanthraquinone by a condensation reaction, the product is demethylated and the 3-methyl group converted to the corresponding 3-carboxy group. The radio-active yield of the total synthesis, starting with 1 Ci 14CO2 is 6,9% (6, 9 mCi); 352 mg 14rhein is produced with a specific activity of 55,7 mCi/mmol. (author)
Additional details
Publishing Information
- Journal Title
- J. Labelled Compd. Radiopharm.
- Journal Volume
- 25
- Journal Issue
- 1
- Series
- J. Labelled Compd. Radiopharm.
- Journal Page Range
- 23-33
- ISSN
- 0362-4803
- CODEN
- JLCRD
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- United Kingdom
- INIS RN
- 19057824
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- ANTHRAQUINONES; CARBON 14 COMPOUNDS; CHEMICAL PREPARATION; CONSTIPATION; LABELLING; LARGE INTESTINE; RADIOPHARMACEUTICALS
- Descriptors DEC
- AROMATICS; BODY; CARBON COMPOUNDS; DIGESTIVE SYSTEM; DRUGS; GASTROINTESTINAL TRACT; INTESTINES; LABELLED COMPOUNDS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; QUINONES; RADIOACTIVE MATERIALS; SYMPTOMS; SYNTHESIS