The value of 18F-FDG SPECT-CT in detecting recurrence or metastasis of cervical cancer

Objective: To evaluate the value of 18F-fluorodeoxyglucose (18F-FDG) SPECT-CT in detecting recurrence and (or) metastasis of cervical cancer. Methods: Retrospective analysis of 62 patients who underwent 18F-FDG SPECT-CT to evaluate recurrence and/or metastasis of cervical cancer at Fujian Tumor Hospital. The diagnostic results were confirmed by second surgery, biopsy or clinical follow-up, and also compared with the coincidence images obtained by CT scan and the serum squamous cell carcinoma related antigen (SCCA) levels. Results: It is confirmed that 36 of 62 patients had recurrence and (or) metastasis of cervical cancer by biopsy or clinical follow-up. The sensitivity, specificity, positivity predictive value (PPV), negative predictive value (NPV), and accuracy of 18F-FDG SPECT-CT were 94.4%, 92.3%, 94.4%, 92.3% and 93.5%. Those of CT scan were 69.4%, 80.8%, 83.3%, 65.6% and 74.2%. Those of SCCA measurement were 66.7%, 46.2%, 63.2%, 50.0% and 58.1%. Conclusion: 18F-FDG SPECT-CT has greater clinical value to monitor recurrence and (or) metastasis of cervical cancer. (authors)