Published July 1978 | Version v1
Journal article Metadata-only

Recurrent pneumonias following intrauterine irradiation of the thymus

Creators

  • 1. Muenchen Univ. (Germany, F.R.). Kinderklinik
  • 2. Medizinische Hochschule Hannover (Germany, F.R.). Kinderklinik

Description

A 9 year old girl is described who was born without thyroid function as a result of maternal 131I treatment during early pregnancy. The patient had 15 pneumonias since her second year of life. Immunological investigations showed normal humoral immunity and a normal in vitro responsiveness of circulating lymphocytes. The patient was, however, anergic to 5 skintest antigens and exhibited a primary vaccination reaction after a smallpox revaccination. The findings suggest that intrauterine irradiation primarily affected memory-lymphocytes. (orig.)

Abstract (German)

Ein neunjaehriges Maedchen wird beschrieben, das als Folge einer 131Jod-Behandlung seiner Mutter waehrend der Fruehschwangerschaft athyreot geboren wurde. Die Patientin hatte seit dem 2. Lebensjahr 15 Pneumonien. Immunologische Untersuchungen ergaben normale humorale Reaktionen und eine normale Stimulierbarkeit von Blutlymphozyten in vitro. Die Patientin war jedoch anergisch gegen 5 Hautantigene und reagierte auf eine Wiederimpfung gegen Pocken mit der Bildung einer Primaerpapel. Die Befunde weisen auf die Moeglichkeit hin, dass die intrauterin erfolgte Bestrahlung in einer bevorzugten Schaedigung von Memory-Lymphozyten resultierte. (orig.)

Additional details

Additional titles

Original title (German)
Rezidivierende Pneumonien nach intrauteriner Bestrahlung des Thymus

Publishing Information

Journal Title
Monatsschr. Kinderheilkd.
Journal Volume
126
Journal Issue
7
Series
Monatsschr. Kinderheilkd.
Journal Page Range
445-447

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
10441224
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CHILDREN; IMMUNITY; IODINE 131; LOCAL RADIATION EFFECTS; LYMPHOCYTES; PATIENTS; PNEUMONIA; PREGNANCY; PRENATAL IRRADIATION; RADIONUCLIDE ADMINISTRATION; THYMUS; THYROID
Descriptors DEC
ANIMAL CELLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DAYS LIVING RADIOISOTOPES; DISEASES; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; IRRADIATION; ISOTOPES; LEUKOCYTES; LYMPHATIC SYSTEM; MAMMALS; MAN; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PRIMATES; RADIATION EFFECTS; RADIOISOTOPES; RESPIRATORY SYSTEM DISEASES; SOMATIC CELLS; VERTEBRATES