Tumorigenesis in infant C3H/HeN mice exposed to tritiated water (HTO)
- 1. Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine
Description
The purpose of this study was to determine the carcinogenicity and retention of tritiated water (HTO) in mice. A two-part study was undertaken. In an HTO-incorporation study, both sexes of 12-day old C3H/HeN mice were intraperitoneal (i.p.) injected with 3.70 MBq/pup of HTO and sacrificed 3 hr and 1, 3, 7, 14 days after HTO administration; in a carcinogenicity study, pups were given a single i.p. injection of HTO at doses of 0, 0.23, 0.92 and 3.70 MBq/mouse, and then observed for 14 months. The survival rates of both sexes slightly decreased upon increasing the HTO administered doses. The results indicated that the administration of HTO to infants led to a significant increase of liver tumors in male mice, but not in females. In female mice, ovarian tumors were observed for the high-dose group of injected HTO. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Radiation Research
- Journal Volume
- 43
- Journal Issue
- 4
- Journal Page Range
- p. 345-351
- ISSN
- 0449-3060
INIS
- Country of Publication
- Japan
- Country of Input or Organization
- Japan
- INIS RN
- 34034704
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL RADIATION EFFECTS; CARCINOGENESIS; DAILY VARIATIONS; DOSE-RESPONSE RELATIONSHIPS; LIVER; MICE; OVARIES; RADIONUCLIDE ADMINISTRATION; SEX DEPENDENCE; SPLEEN; SURVIVAL CURVES; TESTES; TRITIUM OXIDES
- Descriptors DEC
- ANIMALS; BIOLOGICAL EFFECTS; BODY; CHALCOGENIDES; DIGESTIVE SYSTEM; FEMALE GENITALS; GLANDS; GONADS; HYDROGEN COMPOUNDS; MALE GENITALS; MAMMALS; ORGANS; OXIDES; OXYGEN COMPOUNDS; PATHOGENESIS; RADIATION EFFECTS; RODENTS; TRITIUM COMPOUNDS; VARIATIONS; VERTEBRATES; WATER