Extragalactic stellar astronomy with the brightest stars in the universe

Supergiants are objects in transition from the blue to the red (and vice versa) in the uppermost HRD. They are the intrinsically brightest 'normal' stars at visual light with absolute visual magnitudes up to -9. They are ideal to study young stellar populations in galaxies beyond the Local Group to determine chemical composition and evolution, interstellar extinction, reddening laws and distances. We discuss the most recent results on the quantitative spectral analysis of such objects in galaxies beyond the Local Group based on medium and low-resolution spectra obtained with the ESO VLT and Keck. We describe the analysis method including the determination of metallicity and metallicity gradients. A new method to measure extragalactic distances accurately based on stellar gravities and effective temperatures is presented, the flux-weighted gravity-luminosity relationship (FGLR). The FGLR is a purely spectroscopic method that overcomes the uncertainties, introduced by interstellar extinction and variations of metallicity, which plague all methods of photometric stellar distance determination. We discuss the perspectives of future work using the giant ground-based telescopes of the next generation such as the TMT, the GMT and the E-ELT.