Published June 1987
| Version v1
Journal article
Development of an animal model using a closed system to study the sensitivity of a radiopharmaceutical for the detection of gastrointestinal bleeding
Creators
- 1. Kuwait Univ. Dept. of Nuclear Medicine
- 2. Kuwait Univ. Dept. of Surgery
Description
An experimental animal model using a closed system to study the sensitivity of radiopharmaceuticals for the detection and localization of gastrointestinal (GI) bleeding site in a sheep was developed. This model was validated with 99mTc-DTPA. Radioactivity as low as 85.47 ± 13.32 kBq in a volume of 2.1 ± 0.14 ml at a bleeding rate of 0.07 ml/min was detected. Simulated intermittent bleeding experiments indicated that at 1 h after injection of 99mTc-DTPA there was still enough circulating radioactivity to bleed into the gut and that it was possible to perform repeat injection of 99mTc-DTPA as early as 2 h after the first injection. (orig.)
Abstract (German)
Ein experimentelles Tiermodell (geschlossenes System) wurde entwickelt, das die Sensitivitaet einzelner Radiopharmazeutika in der Entdeckung und Lokalisation gastrointestinaler Blutungen ermoeglicht. Dieses Modell wurde am Schaf mit 99mTc-DTPA erprobt. Hiermit konnten Blutungsmengen von 0.07 ml/min (85,47 ± 13,32 kBq/2,1 ± 0,14 ml) entdeckt werden. Die Simulation einer intermittierenden Blutung ergab, dass eine Stunde nach der Injektion von 99mTc-DTPA ausreichende Radioaktivitaetsmengen im Blut zirkulieren, um auch dann Blutungen nachzuweisen. Auch die Reinjektion des Tracers nach zwei Stunden erwies sich als brauchbarer Weg. (orig.)Additional details
Publishing Information
- Journal Title
- Nuklearmedizin
- Journal Volume
- 26
- Journal Issue
- 3
- Series
- Nuklearmedizin.
- Journal Page Range
- 126-130
- ISSN
- 0029-5566
- CODEN
- NUKLD
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 19027216
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; DTPA; FLOW MODELS; FLOW RATE; GASTROINTESTINAL TRACT; HEMORRHAGE; ISOMERIC NUCLEI; RADIOPHARMACEUTICALS; SCINTISCANNING; SENSITIVITY; SHEEP; TECHNETIUM 99
- Descriptors DEC
- AMINO ACIDS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHELATING AGENTS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DIGESTIVE SYSTEM; DISEASES; DOMESTIC ANIMALS; DRUGS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MATHEMATICAL MODELS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; RADIOACTIVE MATERIALS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RUMINANTS; SYMPTOMS; TECHNETIUM ISOTOPES; VERTEBRATES; YEARS LIVING RADIOISOTOPES