Evaluation of stereotactic body radiotherapy for lung cancer using four-dimensional CT-based treatment planning with or without respiratory gating

Eleven patients with non-small cell lung cancer (T1N0M0, n=9; T2N0M0, n=2) and 7 patients with metastatic lung cancer were treated between Oct 2008 and Aug 2010. We defined the target volume using four-dimensional CT image data, with seven patients treated with respiratory gating. The prescription dose was 48 Gy in 4 fractions at the isocenter. The median follow-up period was 12 months (range, 6-29 months). The actuarial 1-year local progression-free rate was 94%. Grade 2 and 3 radiation pneumonitis occurred in 3 and 1 of the patients, respectively. Good local control was achieved with acceptable toxicity although the follow-up period was short. (author)