Published February 2014 | Version v1
Journal article Metadata-only

Synchrotron X-ray powder diffraction data of LASSBio-1515: A new N-acylhydrazone derivative compound

Creators

  • 1. Laboratório de Instrumentação Nuclear/COPPE, UFRJ, Cx Postal 68.509, Rio de Janeiro, RJ (Brazil)
  • 2. Centro de Ciências Naturais e Humanas (CCNH), UFABC, Av. dos Estados, 5001, CEP: 09210-580, Santo André, SP (Brazil)
  • 3. Programa de pós-Graduação em Química, Instituto de Química, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, RJ (Brazil)
  • 4. Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Faculdade de Farmácia, UFRJ, Cx Postal: 68.006, Rio de Janeiro, RJ (Brazil)
  • 5. Instituto de Física, UERJ, CEP: 20550-900, Rio de Janeiro, RJ (Brazil)

Description

In this work, synchrotron X-ray powder diffraction data allowed for a successful indexing of LASSBio-1515 compound, candidate to analgesic and anti-inflammatory activity. X-ray powder diffraction data collected in transmission and high-throughput geometries were used to analyze this compound. The X-ray wavelength of the synchrotron radiation used in this study was determined to be λ=1.55054 Å. LASSBio-1515 was found to be monoclinic with space group P21/c and unit cell parameters a=11.26255(16) Å, b=12.59785(16) Å, c=8.8540(1) Å, β=90.5972(7)° and V=1256.17(3) Å3. - Highlights: ► LASSBio-1515 is a new N-acylhydrozone derivative compound. ► Molecular simplification strategy used in the rational planning of LASSBio-1515. ► Synchrotron XRPD data allowed for a successful indexing of LASSBio-1515 compound. ► This was indexed as having a monoclinic system (P21/c)

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radphyschem.2013.02.014

Additional details

Identifiers

DOI
10.1016/j.radphyschem.2013.02.014;
PII
S0969-806X(13)00073-X;

Publishing Information

Journal Title
Radiation Physics and Chemistry (1993)
Journal Volume
95
Journal Page Range
p. 292-295
ISSN
0969-806X
CODEN
RPCHDM

Conference

Title
12. international symposium on radiation physics
Acronym
ISRP 2012
Dates
7-12 Oct 2012
Place
Rio de Janeiro (Brazil)

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
45111305
Subject category
S36: MATERIALS SCIENCE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
GEOMETRY; HYDRAZONES; INFLAMMATION; MONOCLINIC LATTICES; POWDERS; SPACE GROUPS; SYNCHROTRON RADIATION; SYNCHROTRONS; X-RAY DIFFRACTION
Descriptors DEC
ACCELERATORS; BREMSSTRAHLUNG; COHERENT SCATTERING; CRYSTAL LATTICES; CRYSTAL STRUCTURE; CYCLIC ACCELERATORS; DIFFRACTION; ELECTROMAGNETIC RADIATION; MATHEMATICS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOLOGICAL CHANGES; RADIATIONS; SCATTERING; SYMMETRY GROUPS; SYMPTOMS

Optional Information

Copyright
Copyright (c) 2013 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.