Published October 1993 | Version v1
Journal article Metadata-only

Effects of 60Co-γ-ray and cyclophosphamide on the contents of monoamine neurotransmitters in hypothalamus of rats

Creators

  • 1. Changhai Hospital, Shanghai (China). Dept. of Traditional Chinese Medicine

Description

The model of rats irradiated by 60Co-γ-ray(60Co) or injected by cyclophosphamide (Cy) was studied. It was found that the contents of monoamine neurotransmitters change greatly in the hypothalamus in both kinds of model. The contents of noradrenaline (NA) and dopamine (DA), and the ratio of DA to DOPAC increased significantly in hypothalamus of rats irradiated by 60Co. The contents of NA and the ratio of 5-hydroxyamine (5-HT) to 5-hychoxyindole acetic acid (5-HIAA) decreased markedly in lamus of rats injected by Cy. The author thinks that there is a certain relation between the monoamine neurotransmitters and the activity of methylation of NA and monoamine oxidase

Additional details

Publishing Information

Journal Title
Academic Journal of Second Military Medical University
Journal Volume
14
Journal Issue
5
Journal Page Range
p. 432-434.
ISSN
0258-879X
CODEN
DJXUE5

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
25036351
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; COBALT 60; DOPAMINE; ENDOXAN; GAMMA RADIATION; HYPOTHALAMUS; NORADRENALINE; RATS; WHOLE-BODY IRRADIATION
Descriptors DEC
ADRENAL HORMONES; ALKYLATING AGENTS; AMINES; ANIMALS; ANTIMITOTIC DRUGS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; BRAIN; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COBALT ISOTOPES; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HORMONES; HYDROXY COMPOUNDS; IMMUNOSUPPRESSIVE DRUGS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SYMPATHOMIMETICS; VERTEBRATES; YEARS LIVING RADIOISOTOPES