Published September 2006 | Version v1
Journal article Metadata-only

Complexation between Venlafaxine Hydrochloride and β -Cyclodextrin: Structural Study by Nuclear Magnetic Resonance Spectroscopy

Creators

  • 1. Aligarh Muslim University, Aligarh (India)
  • 2. Gifu University, Gifu (Japan)

Description

A detailed spectroscopic study (1H NMR, COSY, ROESY) of complexation of venlafaxine hydrochloride (VEN) with β-cyclodextrin (β-CD) was carried out in solution. The stoichiometry of the complex was determined to be 1 : 1 and penetration of aromatic ring into β-Cyclodextrin cavity was confirmed from primary rim side, with the help of ROESY spectral data. The structure of the venlafaxine hydrochloride-β-CD complex has been proposed. The association constant was determined to be 234 M-1

Additional details

Publishing Information

Journal Title
Bulletin of the Korean Chemical Society
Journal Volume
27
Journal Issue
9
Series
14 refs, 6 figs, 1 tab
Journal Page Range
p. 1397-1400
ISSN
0253-2964

INIS

Country of Publication
Korea, Republic of
Country of Input or Organization
Korea, Republic of
INIS RN
49099424
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
AROMATICS; NUCLEAR MAGNETIC RESONANCE; RESONANCE IONIZATION MASS SPECTROSCOPY; SPECTRA; STOICHIOMETRY
Descriptors DEC
HYDROCARBONS; MAGNETIC RESONANCE; MASS SPECTROSCOPY; ORGANIC COMPOUNDS; RESONANCE; SPECTROSCOPY