Published November 1975 | Version v1
Journal article Metadata-only

Radioimmune assay of heterologous serum γ-globulin in patients receiving rabbit antihuman thymocyte globulin

Creators

  • 1. Stanford Univ., CA

Description

A radioimmune assay (RIA) method for detecting heterologous serum rabbit γ-globulin (RG) and antibody to this protein is described. The methodology is used for monitoring serum levels of rabbit globulin in patients receiving rabbit ATG (RATG). In 7 cardiac recipients receiving RATG, maximum serum levels of RG were achieved 1 to 3 days after administration of final dose. RG half-life subsequent to peak serum levels was rapid (X = 36 hr) in 4 patients and prolonged (X = 18 days) in 3 patients. Patient antibody to rabbit γ-globulin was detectable only in those patients with short RG half-life. Antirabbit antibody titers in these patients were extremely low and barely detectable by RIA

Additional details

Additional titles

Augmented title (English)
"1"2"5I tracer technique

Identifiers

DOI
10.1097/00007890-197511000-00006;

Publishing Information

Journal Title
Transplantation
Journal Volume
20
Journal Issue
5
Series
Transplantation.
Journal Page Range
393-398
ISSN
0041-1337

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
7236923
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ANTIBODIES; GLOBULINS-GAMMA; IMMUNE SERUMS; IODINE 125; PATIENTS; RABBITS; RADIOIMMUNOASSAY; TRACER TECHNIQUES
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; GLOBULINS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; VERTEBRATES

Optional Information

Notes
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