Published April 1982 | Version v1
Journal article Metadata-only

Synthesis of radioactively methyl-labelled (1)-carnitine

Creators

  • 1. Case Western Reserve Univ., Cleveland, OH (USA). School of Medicine

Description

Commercial (l)-carnitine chloride was N-demethylated by the action of sodium benzenemercaptide in warm N,N-dimethylformamide. The product 4-(N,N-dimethylammonio)-3-hydroxybutanoic acid chloride salt was isolated in good yield by ion exchange chromatography. Methylation of the product by 14C -iodomethane in dry methanol produced biologically active 4-N-Me-14C -(l)-carnitine chloride of high specific activity in excellent yield. (author)

Additional details

Publishing Information

Journal Title
J. Labelled Compd. Radiopharm.
Journal Volume
19
Journal Issue
4
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
535-541

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
13695134
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BUTYRIC ACID; CARBON 14 COMPOUNDS; CARNITINE; CHEMICAL PREPARATION; CHEMICAL REACTION YIELD; HYDROXY COMPOUNDS; ION EXCHANGE CHROMATOGRAPHY; ISOMERS; LABELLED COMPOUNDS; METHANE; METHYLATION; ORGANIC CHLORINE COMPOUNDS; ORGANIC IODINE COMPOUNDS
Descriptors DEC
ALKANES; AMINO ACIDS; CARBON COMPOUNDS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; CHROMATOGRAPHY; HYDROCARBONS; HYDROXY ACIDS; MONOCARBOXYLIC ACIDS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; SEPARATION PROCESSES; SYNTHESIS; VITAMIN B GROUP; VITAMINS