Published July 1980 | Version v1
Journal article Metadata-only

Numerical relationship between cells with radiation-induced chromosome aberrations and cells lethally injured by radiation

Creators

  • 1. Goettingen Univ. (Germany, F.R.). Inst. fuer Medizinische Physik und Biophysik

Description

The numerical relationship between radiation-induced chromosome aberrations in human G0 lymphocytes and reproductive lethality of human bone-marrow lymphocytes is analysed within a large LET interval. The comparison is based upon the evaluation of the coefficient α of the linear component of the corresponding dose-effect-relation for the frequency of cells without aberrations and for the frequency of surviving cells. The good correlation between these coefficients over a large LET interval supports the hypothesis that structural chromosome aberrations and reproductive cell death both result from the same gross chromatin damage. (orig.)

Abstract (German)

Die numerische Beziehung zwischen strahleninduzierten Chromosomenaberrationen bei menschlichen G0-Lymphozyten und der reproduktiven Letalitaet menschlicher Knochemarkslymphozyten wird mit grossem LET-Intervall untersucht. Der Vergleich beruht auf der Analyse des Koeffizienten α der linearen Komponente der Dosiswirkungs-Beziehung fuer die Haeufigkeit von Zellen ohne Aberrationen bzw. die Haeufigkeit ueberlebender Zellen. Die gute Beziehung zwischen diesen Koeffizienten bei grossem LET-Intervall unterstuetzt die Annahme, dass sowohl strukturelle Chromosomenaberrationen als auch der reproduktive Zelltod vom gleichen Chromatinschaden herruehren. (orig.)

Additional details

Publishing Information

Journal Title
Radiat. Environ. Biophys.
Journal Volume
18
Journal Issue
1
Series
Radiat. Environ. Biophys.
Journal Page Range
73-77
ISSN
0301-634X

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
11569931
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
CELL KILLING; CHROMOSOMAL ABERRATIONS; DOSE-RESPONSE RELATIONSHIPS; ELECTRON BEAMS; IRRADIATION; LET; LETHAL IRRADIATION; LYMPHOCYTES; MEV RANGE 10-100; RADIATION INJURIES; SURVIVAL CURVES; X RADIATION
Descriptors DEC
ANIMAL CELLS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; ENERGY RANGE; ENERGY TRANSFER; INJURIES; IONIZING RADIATIONS; LEPTON BEAMS; LEUKOCYTES; MEV RANGE; MUTATIONS; PARTICLE BEAMS; RADIATION EFFECTS; RADIATIONS; SOMATIC CELLS