Synthesis and evaluation of 125I 2-aminophenylthio-5-iodo-N,N-dimethyl benzylamine for Exploration of Serotonin Transporter Exploration
- 1. Department of Applied Radiation and Isotopes, Faculty of Science, Kasetsart University, Bangkok (Thailand)
- 2. INSERM, France, Universite Francois-Rabelais, de Tours (France)
Description
Full text: Serotonin transporter (T-5-HT) plays an important roles in the control of serotoninergic neurotransmission in both amplitude and interaction period. The imbalance in serotoninergic neurotransmission leads to neuropsychiatric symptom such as depression and in neuro degenerative diseases, Parkinson and Alzheimer diseases. In the present study, the [125I] 2-aminophenylthio-5-iodo-N,N-dimethyl benzylamine, a derivative of the 2-[[2-((dimethylamino)methyl)phenyl]thio]-5-iodo phenylamine (ADAM) was synthesized with iodine atom transferred from aniline ring of ADAM to the N,N-dimethyl benzylamine ring by chemical synthesis. The I-125 labeling efficiency was 60%. It is expected that this will be useful for serotonin transporter exploration
Availability note (English)
Available in abstract form only, full text entered this recordAdditional details
Publishing Information
- Imprint Pagination
- 1 p.
- Report number
- INIS-TH--299
Conference
- Title
- 11. Conference on Nuclear Science and Technology
- Dates
- 2-3 Jul 2009
- Place
- Bangkok (Thailand)
INIS
- Country of Publication
- Thailand
- Country of Input or Organization
- Thailand
- INIS RN
- 43050937
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Resource subtype / Literary indicator
- Conference, Numerical Data, Non-conventional Literature
- Descriptors DEI
- DERIVATIZATION; EXPERIMENTAL DATA; IODINE 125; LABELLED COMPOUNDS; SEROTONIN; TRANSPORT
- Descriptors DEC
- AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BETA DECAY RADIOISOTOPES; CHEMICAL REACTIONS; DATA; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INDOLES; INFORMATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODINE ISOTOPES; ISOTOPES; NEUROREGULATORS; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRROLES; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SYMPATHOMIMETICS; TRYPTAMINES