Search for anti-radiation immunomodulators

The research objective: Creation of the effective radio-protectors and immunomodulators against radiation and its testing. To achieve the intended goals, the following tasks are to be done: - to study the radiomodifying and immunity-correcting properties of the preparation; - to test it in combination with other preparations, - to produce new radioprotectors and immunomodulators on a base of the organs and tissues of various animals, including the simplest vertebrates, at the contaminated territories, and its tests; - to test existing preparations possessing the property to suppress tumours as the candidates for a role of radioprotector in a case of low-dose irradiation. - Collection of raw materials (organs and tissues of animals), its transportation, fractionating, dialysis are carried out at low temperature in order to fractionating, dialysis are carried out at low temperature in order to preserve activity of the produced preparations. - Determination of biological activity is performed by a specific technique with white linear mouse: - determination of the spectrum and other features are made by ordinary methods; irradiation of laboratory animals is executed at medicine X-ray devices. Expected Results: Technology for production of the radioprotectors and preparations with specified immunomodulating property on a base of lymphoid and endocrine organs of various kinds of animals will be developed. After tests the most effective, prospecting preparations, possessing high biological activity and low toxic action will be selected; its doses will be determined. The prospecting and effective preparations will be transferred for clinic tests