Published April 1992 | Version v1
Journal article Metadata-only

Radioprotection of mice by the bacterial extract Broncho-VaxonR: haemopoietic stem cells and survival enhancement

Creators

  • 1. P.J. Safarik Univ., Kosice (Czechoslovakia). Dept. of Cellular and Molecular Biology

Description

Pretreatment of mice with 50-1000 μg of the bacterial extract Broncho-VaxomR (BV, free of endotoxin) before sublethal irradiation induced an increase in the number of endogenous haemopoietic stem cells (E-CFU). The degree of radioprotection was dependent on both the time of administration and the dose of BV. An optimal E-CFU survival was observed when 500 μg of BV was administered i.p. 24h before irradiation. (author)

Additional details

Publishing Information

Journal Title
International Journal of Radiation Biology
Journal Volume
61
Journal Issue
4
Series
Int. J. Radiat. Biol.
Journal Page Range
511-518
ISSN
0955-3002
CODEN
IJRBE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
23057971
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BACTERIA; CFU; IMMUNOSUPPRESSION; MICE; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; STEM CELLS; SUBLETHAL IRRADIATION; SURVIVAL CURVES
Descriptors DEC
ANIMAL CELLS; ANIMALS; DRUGS; IRRADIATION; MAMMALS; MICROORGANISMS; RODENTS; SOMATIC CELLS; VERTEBRATES