Research advance on molecular imaging of tumor angiogenesis with SPECT

Tumor Angiogenesis is one of the key requirements of tumor growth and metastasis. Tumour-induced angiogenesis is a multistep process that controlled by growth factors, cellular receptors and adhesion molecules, such as vascular endothelial growth factor, αvβ3 integrin, extracellular matrix proteins, prostate-specific membrane antige. They have become a common molecular target which has a potential value in angiogenesis molecular imaging and therapy at present. It is an important subject of modern medical imaging in developing a new imaging method which can accurate noninvasive assessment of tumor angiogenesis and tumor anti-angiogenesis therapy effect. (authors)