Published February 2010 | Version v1
Journal article Metadata-only

Radiosynthesis of N-[11C]-methyl-hydroxyfasudil as a new potential PET radiotracer for rho-kinases (ROCKs)

Creators

  • 1. National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ont., K1Y 4W7 (Canada)
  • 2. TRIUMF Canada's National Laboratory for Particle and Nuclear Physics , Vancouver, BC (Canada)
  • 3. Division of Cardiology (Department of Medicine) and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ont. (Canada)

Description

N-[11C]-methyl-hydroxyfasudil was synthesized as a new potential radiotracer for rho-kinases (ROCKs) via a two-step one-pot radiosynthesis. The first step was the methylation of the precursor N-Boc-hydroxyfasudil-sodium salt/benzo-15-crown-5 complex with [11C]methyl iodide. The second step involved deprotection of the tert-butoxycarbonyl protecting group. The radiochemical and chemical purities of N-[11C]-methyl-hydroxyfasudil were >95% and specific radioactivity was 1565-2565 mCi/μmol at the end of the synthesis.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2009.11.002

Additional details

Identifiers

DOI
10.1016/j.apradiso.2009.11.002;
PII
S0969-8043(09)00691-5;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
68
Journal Issue
2
Journal Page Range
p. 325-328
ISSN
0969-8043
CODEN
ARISEF

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
41062563
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Descriptors DEI
CARBON 11; CROWN ETHERS; LABELLING; METHYLATION; PHOSPHOTRANSFERASES; RADIOACTIVITY; RADIOPHARMACEUTICALS; SODIUM COMPOUNDS; SYNTHESIS; TRACER TECHNIQUES
Descriptors DEC
ALKALI METAL COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CHEMICAL REACTIONS; DRUGS; ENZYMES; ETHERS; EVEN-ODD NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PHOSPHORUS-GROUP TRANSFERASES; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TRANSFERASES

Optional Information

Copyright
Copyright (c) 2009 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.