Published February 2015 | Version v1
Journal article Metadata-only

PET imaging with 68Gallium labelled somatostatin analogues in the evaluation of neuroendocrine tumours (NETs)

Creators

  • 1. CHU Hotel Dieu, service de Medecine Nucleaire, 1, place Alexis-Ricordeau, 44093 Nantes cedex 01 (France)
  • 2. CHU La Timone, service de Medecine Nucleaire, 264, rue Saint-Pierre, 13385 Marseille cedex 05 (France)
  • 3. Hopital Tenon, service de Medecine Nucleaire, 4, rue de la Chine, 75970 Paris cedex 20 (France)
  • 4. Groupe Hospitalier Cochin, service de Medecine Nucleaire, 27, rue du Faubourg-Saint-Jacques, 75679 Paris cedex 14 (France)

Description

Neuroendocrine tumours (NETs) are rare tumours arising from cells of the nervous and endocrine systems. Since the 1990's, the use of somatostatin analogues (SSTa) imaging for NETs evaluation has allowed a better understanding of these neoplasms. Recent 68Gallium labelled somatostatin analogues with higher affinity for somatostatin receptors are now available for PET/CT imaging of NETs, leading to new imaging protocols for patient care. Three new analogues (DOTATOC, DOTANOC, DOTATATE) were superior to OctreoScan1, and conventional imaging for lesion detection. In this article, recent publications on the diagnostic and care of gastroenteropancreatic (GEP) tumours, pheochromocytomas/ paragangliomas (PPGLs), unknown primary tumours, medullary thyroid carcinomas (MTC), Merkel tumours and Cushing syndrome with ectopic ACTH hypersecretion are reviewed. (authors)

Availability note (English)

Available from doi: http://dx.doi.org/10.1016/j.mednuc.2015.02.007

Abstract (French)

Les TNE sont un groupe de tumeurs rares dont la connaissance a ete tres largement amelioree dans les annees 1990 par l'imagerie des recepteurs de la somatostatine par scintigraphie (OctreoScan1). Recemment, des analogues encore plus affins pour les recepteurs ont ete etudies, ils sont marques au 68Gallium et permettent donc une imagerie TEP/TDM. Trois de ces analogues (DOTATOC, DOTANOC, DOTATATE) ont montre leur superiorite pour la detection de lesions tumorales neuro-endocrines par rapport a l'OctreoScan1, et a l'imagerie conventionnelle. Dans cet article, nous faisons une revue recente des donnees de la litterature dans les principales tumeurs neuro-endocrines gastro-enteropancreatique (GEP), pheochromocytomes/paragangliomes, cancer medullaire de la thyroide, tumeurs de Merkel et syndrome de Cushing avec secretion ectopique d'ACTH. (auteurs)

Additional details

Additional titles

Original title (French)
L'imagerie des recepteurs de la somatostatine par les DOTA peptides marques au Gallium 68 dans les tumeurs neuro-endocrines

Identifiers

DOI
10.1016/j.mednuc.2015.02.007;

Publishing Information

Journal Title
Medecine Nucleaire. Imagerie Fonctionnelle et Metabolique
Journal Volume
39
Journal Issue
no.1
Journal Page Range
p. 18-25
ISSN
0928-1258
CODEN
MNIMEX

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
53085770
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACTH; CARCINOMAS; CUSHING SYNDROME; EVALUATION; GALLIUM; PATIENTS; POSITRON COMPUTED TOMOGRAPHY; RECEPTORS; REVIEWS; SOMATOSTATIN; THYROID
Descriptors DEC
BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DOCUMENT TYPES; ELEMENTS; EMISSION COMPUTED TOMOGRAPHY; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GLANDS; HORMONES; MEMBRANE PROTEINS; METALS; NEOPLASMS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; TOMOGRAPHY

Optional Information

Notes
61 refs.