The effect of metal salts on the distribution of iron-59 in rats: Manganese (II), nickel (II) and tin (II)

The disappearance and reappearance of iron-59 in plasma and blood at various time intervals has been studied in control, manganese, nickel and tin administered and anaemic rats after a single intraveneous injection of an aqueous solution of radioactive iron (III) citrate. Significant difference was observed in the rate of reappearance of iron-59 in the circulation between control and manganese treated animals. The disappearance of iron-59 from the plasma of control and treated animals however did not show any appreciable difference. A significant increase in the radio-iron content was observed in bone marrow, liver and kidney of treated animals as compared to control group forty eight hours after Fe-59. (author)