Published November 2019 | Version v1
Journal article Metadata-only

Electrochemical determination of the antipsychotic medication clozapine by a carbon paste electrode modified with a nanostructure prepared from titania nanoparticles and copper oxide

Creators

  • 1. Baqiyatallah University of Medical Sciences, Chemical Injuries Research Center, Systems Biology and Poisonings Institute (Iran, Islamic Republic of)
  • 2. University of Ilam, Department of Chemistry (Iran, Islamic Republic of)
  • 3. Islamic Azad University, Young Researchers and Elite Club, Karaj Branch (Iran, Islamic Republic of)
  • 4. Kermanshah University of Medical Sciences, Pharmaceutical Sciences Research Center, School of Pharmacy (Iran, Islamic Republic of)
  • 5. Kashan University of Medical Sciences, Social Determinants of Health (SDH) Research Center (Iran, Islamic Republic of)
  • 6. Kharazmi University, Faculty of Chemistry (Iran, Islamic Republic of)
  • 7. University of Tehran, Center of Excellence in Electrochemistry (Iran, Islamic Republic of)
  • 8. Iran University of Medical Sciences, Physiology Research Center (Iran, Islamic Republic of)

Description

A nanostructure was prepared from titania nanoparticles and copper oxide (TiO2NP@CuO) and used to modify a carbon paste electrode (CPE). The modified CPE is shown to enable sensitive voltammetric determination of the drug clozapine (CLZ). The sensor was characterized by various techniques and some key parameters were optimized. Under the optimum conditions and at a working potential of 0.6 V (vs. Ag/AgCl), the modified CPE has two linear response ranges, one from 30 pmol L−1 to 4 nmol L−1 of CLZ, the other from 4 nmol L−1 to 10 μmol L−1. The detection limit is as low as 9 pM. The transfer coefficient (α) and catalytic rate constant (kcat) were calculated and the reliability of the sensor was estimated for CLZ sensing in real samples where it gave satisfactory results.

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Additional details

Identifiers

DOI
10.1007/s00604-019-3760-7;

Publishing Information

Journal Title
Mikrochimica Acta
Journal Volume
186
Journal Issue
11
Journal Page Range
p. 1-10
ISSN
0026-3672
CODEN
MIACAQ

INIS

Country of Publication
Austria
Country of Input or Organization
Austria
INIS RN
52067367
Subject category
S77: NANOSCIENCE AND NANOTECHNOLOGY; S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
AROMATICS; COPPER OXIDES; ELECTROCHEMISTRY; HETEROCYCLIC COMPOUNDS; NANOCHEMISTRY; NANOPARTICLES; NANOSTRUCTURES; ORGANIC NITROGEN COMPOUNDS; PIPERAZINES; POLAROGRAPHY; TITANIUM OXIDES
Descriptors DEC
AZINES; CHALCOGENIDES; CHEMISTRY; COPPER COMPOUNDS; DEVELOPERS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; PARTICLES; PYRAZINES; TITANIUM COMPOUNDS; TRANSITION ELEMENT COMPOUNDS

Optional Information

Copyright
Copyright (c) 2019 Springer-Verlag GmbH Austria, part of Springer Nature