Diagnosis of thyroid carcinoma using 99TcmO4-/99Tcm-HL 91 imaging

Objective: To evaluate the clinical value of 99Tcm-sodium pertechnetate (99TcmO4-) and 99Tcm-4, 9-diaza-3, 3, 10, 10-tetramethylododecan-2, 11-dione dioxime (99Tcm-HL91) imaging in differentiation of thyroid nodules. Methods: 99TcmO4- dynamic and static imagings were performed to the 65 cases of patients with thyroid nodules. After 48 hours, the 46 cases of patients whose 99TcmO4- static imaging prompt cold nodules underwent 99Tcm-HL91 hypoxia imaging. And finally, compare the results of the two types imaging with biopsy results. Results: The sensitivity, specificity and accuracy of 99TcmO4- imaging in the diagnosis of thyroid nodules were 78.6%, 71.9% and 73.9% respectively. The sensitivity, specificity and accuracy of 99Tcm-HL91 imaging in the diagnosis of thyroid nodules were 88.7%, 92.3% and 91.4 % respectively. And the sensitivity, specificity and accuracy of Combining 99TcmO4-/99TcmO4-HL91 imaging were 92.9%, 93.8% and 93.5% respectively. Conclusion: Combining 99TcmO4- and 99Tcm-HL91 imaging methods can improve the coincidence. (authors)