Published October 2004
| Version v1
Journal article
227Th-EDTMP: A potential therapeutic agent for bone metastasis
Description
The biodistribution of 227Th-EDTMP and retention of its daughter nuclide 223Ra were examined. 227Th-EDTMP was found to show high uptake and long-term retention in bone. The clearance of 227Th-EDTMP from blood and soft tissues was rapid and the femur-to-tissue uptake ratios reached more than 100 within 30 min for all tissues except the kidney. Seven and 14 days after injection of 227Th-EDTMP, the retention index of 223Ra in bone showed high values, and the differences between these time points were not significant. Therefore, 227Th-EDTMP is a potential radiotherapeutic agent for bone metastasis
Additional details
Identifiers
- DOI
- 10.1016/j.nucmedbio.2004.05.001;
- PII
- S0969805104000782;
Publishing Information
- Journal Title
- Nuclear Medicine and Biology
- Journal Volume
- 31
- Journal Issue
- 7
- Journal Page Range
- p. 901-908
- ISSN
- 0969-8051
- CODEN
- NMBIEO
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 36022099
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BLOOD; BLOOD-PLASMA CLEARANCE; BONE TISSUES; DRUGS; FEMUR; IN VIVO; KIDNEYS; METASTASES; RADIONUCLIDE KINETICS; RADIUM 223; RETENTION; THORIUM 227; UPTAKE
- Descriptors DEC
- ACTINIDE NUCLEI; ALKALINE EARTH ISOTOPES; ALPHA DECAY RADIOISOTOPES; ANIMAL TISSUES; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARBON 14 DECAY RADIOISOTOPES; CLEARANCE; CONNECTIVE TISSUE; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; HEAVY ION DECAY RADIOISOTOPES; HEAVY NUCLEI; ISOTOPES; KINETICS; MATERIALS; NUCLEI; ORGANS; RADIOISOTOPES; RADIUM ISOTOPES; SKELETON; THORIUM ISOTOPES
Optional Information
- Copyright
- Copyright (c) 2004 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.