Comparison of LVEF assessed by conventional gated blood pool SPECT (NaI(Tl)), CZT-planar and CZT-SPECT with planar (NaI(Tl)) using radionuclide ventriculography

Estimation of left ventricular ejection fraction (LVEF) using equilibrium radionuclide ventriculography is an established method for assessment of left ventricular function. This study has been designed to assess the correlation between the LVEF measured by conventional NaI(Tl) detector-based SPECT, dedicated cardiac CZT detector based planar and SPECT with planar MUGA. The patients were acquired on both Philips Bright view XCT Cardiac Camera (SPECT/CT) Netherlands and D-SPECT Cardio from Dynamic Spectrum Israel after in vivo labeling of RBCs with ^99mTc. In D-SPECT system, the patient was positioned in supine position and ROI was drawn on left ventricular cavity. First, SPECT images of patient were acquired, and then planar images were acquired in the in-built software planar MUGA provided by company.Linear regression analysis was done to look for proportional bias between the LVEF results. This study showed good correlation and agreement between NaI(Tl)- Planar to NaI-(Tl)-SPECT and both CZT-Planar and CZT-SPECT. Because of the excellent temporal, spatial, and energy resolution of CZT based D-SPECT can substitute the planar ERNA with advantage of having shorter acquisition time and better image quality. Also, the radiation dose to patient can be minimized