Radiosensitivity of hemopoietic stroma precursors and mature stromal cells in a long-term bone marrow culture

Radiosensitivity of hemopoietic stroma precursors from a long-term culture of murine bone marrow, as measured by the adherent cell layer implantation techniques, was characterized by D0=3.02±0.7 Gy and n=1.6. Mature cells of the hemopoietic microenvironment survived after doses of up to 100 Gy. Their irreversible damage was only observed after 150-200 Gy irradiation. The results obtained support the suggestion of different histogenetical origin of the hemopoietic and stromal precursors