Published 1981
| Version v1
Miscellaneous
Modification of the early and late delayed radiation response of the rat spinal cord by chemotherapeutic agents
- 1. Gezondheidsorganisatie TNO, Rijswijk (Netherlands). Radiobiologisch Inst. TNO
Description
A possible effect of methotrexate (MTX) and cytosine arabinoside (ara-C) on the induction of early and late delayed radiation damage in the CNS was studied in the rat cervical spinal cord. Male WAG/Rij rats were injected intrathecally (i.t.; between lumbar vertebrae 4 and 5) or intravenously (i.v.) with MTX or ara-C, followed 30 min later by X-irradiation. The different reactions observed during the first six months after treatment are presented. The results suggest that i.t. administered ara-C greatly enhances the effect of radiation on oligodendroglial cells involved in the production and maintenance of myelin. MTX, however, shows no modification of the early delayed radiation response of the rat spinal cord. (Auth.)
Additional details
Publishing Information
- Imprint Title
- REP Annual Report 1980
- Imprint Pagination
- 282 p.
- Journal Page Range
- p. 27-30.
- Report number
- INIS-mf--6804
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 13647670
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Progress Report
- Descriptors DEI
- CHEMOTHERAPY; CYTOSINE; DELAYED RADIATION EFFECTS; EARLY RADIATION EFFECTS; METHOTREXATE; RATS; SPINAL CORD; X RADIATION
- Descriptors DEC
- AMINES; ANIMALS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; CENTRAL NERVOUS SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; MAMMALS; MEDICINE; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RODENTS; THERAPY; VERTEBRATES