Comparison of estimated human effective dose of ⁶⁷Ga- and ^99mTc-labeled bombesin based on distribution data in mice

This study describes the preparation, biodistribution and absorbed dose prediction of ⁶⁷Ga and ^99mTc labeled bombesin (BBN) in human organs, after injection in mice determined via medical internal radiation dose. We estimated that a 185-MBq injection of ⁶⁷Ga-BBN into the humans would result in an estimated effective absorbed dose of 2.50 mSv whereas this value for ^99mTc-BBN is 1.33 mSv in the whole body. These results suggest that injection of ⁶⁷Ga-BBN would result 2 times higher absorbed dose compare to ^99mTc-BBN. (author)