Discrepancies in dose volume histograms generated from different treatment planning systems

We analyzed changes in the doses, structure volumes, and dose-volume histograms (DVHs) when data were transferred from one commercial treatment planning system (TPS) to another commercial TPS. A total of 22 volumetric modulated arc therapy (VMAT) plans for nasopharyngeal cancer were generated with the Eclipse system using 6-MV photon beams. The computed tomography (CT) images, dose distributions, and structure information, including the planning target volume (PTV) and organs at risk (OARs), were transferred from the Eclipse to the MRIdian system in digital imaging and communications in medicine (DICOM) format. Thereafter, DVHs of the OARs and PTVs were generated in the MRIdian system. The structure volumes, dose distributions, and DVHs were compared between the MRIdian and Eclipse systems. The dose differences between the two systems were negligible (average matching ratio for every voxel with a 0.1% dose difference criterion=100.0±0.0%). However, the structure volumes significantly differed between the MRIdian and Eclipse systems (volume differences of 743.21±461.91% for the optic chiasm and 8.98±1.98% for the PTV). Compared to the Eclipse system, the MRIdian system generally overestimated the structure volumes (all, p<0.001). The DVHs that were plotted using the relative structure volumes exhibited small differences between the MRIdian and Eclipse systems. In contrast, the DVHs that were plotted using the absolute structure volumes showed large differences between the two TPSs. DVH interpretation between two TPSs should be performed using DVHs plotted with the absolute dose and absolute volume, rather than the relative values