Published December 2015 | Version v1
Journal article Metadata-only

Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

Creators

  • 1. IRCCS S. Matteo Hospital, Pavia (Italy)
  • 2. Department of Clinic-Surgical Sciences, Experimental Surgery Laboratory, University of Pavia (Italy)
  • 3. IGM-CNR and Department of Biology and Biotechnologies "L. Spallanzani", University of Pavia (Italy)
  • 4. INFN (National Institute of Nuclear Physics) Section of Pavia (Italy)
  • 5. Department of Physics, University of Pavia (Italy)
  • 6. CONICET (Argentina)
  • 7. Comisión Nacional de Energía Atómica (CNEA), Buenos Aires (Argentina)

Description

The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.apradiso.2015.07.054

Additional details

Identifiers

DOI
10.1016/j.apradiso.2015.07.054;
PII
S0969-8043(15)30136-6;

Publishing Information

Journal Title
Applied Radiation and Isotopes
Journal Volume
106
Journal Page Range
p. 226-232
ISSN
0969-8043
CODEN
ARISEF

Conference

Title
16. international congress on neutron capture therapy
Acronym
ICNCT-16
Dates
14-19 Jun 2014
Place
Helsinki (Finland)

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
48015354
Subject category
S07: ISOTOPES AND RADIATION SOURCES;
Resource subtype / Literary indicator
Conference
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; BORON; CARCINOMAS; CELL CYCLE; DISTURBANCES; GAMMA RADIATION; IRRADIATION; LIMBS; LIVER; LUNGS; METASTASES; NEUTRON CAPTURE THERAPY; OSTEOSARCOMAS; RADIATION DOSES; RADIOSENSITIVITY; SUSPENSIONS
Descriptors DEC
BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; DISPERSIONS; DOSES; ELECTROMAGNETIC RADIATION; ELEMENTS; GLANDS; IONIZING RADIATIONS; MEDICINE; NEOPLASMS; NEUTRON THERAPY; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RADIOTHERAPY; RESPIRATORY SYSTEM; SARCOMAS; SEMIMETALS; SENSITIVITY; SKELETAL DISEASES; THERAPY

Optional Information

Copyright
Copyright (c) 2015 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.