Published March 20, 2006 | Version v1
Report Metadata-only

MICROFLUIDIC MIXERS FOR THE INVESTIGATION OF PROTEIN FOLDING USING SYNCHROTRON RADIATION CIRCULAR DICHROISM SPECTROSCOPY

Creators

Description

The purpose of this study is to design, fabricate and optimize microfluidic mixers to investigate the kinetics of protein secondary structure formation with Synchrotron Radiation Circular Dichroism (SRCD) spectroscopy. The mixers are designed to rapidly initiate protein folding reaction through the dilution of denaturant. The devices are fabricated out of fused silica, so that they are transparent in the UV. We present characterization of mixing in the fabricated devices, as well as the initial SRCD data on proteins inside the mixers

Availability note (English)

Available from https://e-reports-ext.llnl.gov/pdf/331928.pdf; PURL: https://www.osti.gov/servlets/purl/928522-IC73Dl/

Additional details

Identifiers

URL
https://e-reports-ext.llnl.gov/pdf/331928.pdf; https://www.osti.gov/servlets/purl/928522-IC73Dl/;

Publishing Information

Imprint Pagination
6 p.
Report number
UCRL-PROC--220084

Conference

Title
Hilton Head 2006 Workshop
Dates
4-8 Jun 2006
Place
Hilton Head, SC (United States)

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
39070197
Subject category
S46: INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY;
Resource subtype / Literary indicator
Conference, Non-conventional Literature
Descriptors DEI
DESIGN; DICHROISM; DILUTION; KINETICS; MIXERS; PROTEINS; SILICA; SPECTROSCOPY; SYNCHROTRON RADIATION
Descriptors DEC
BREMSSTRAHLUNG; ELECTROMAGNETIC RADIATION; EQUIPMENT; MATERIALS HANDLING EQUIPMENT; MINERALS; ORGANIC COMPOUNDS; OXIDE MINERALS; RADIATIONS

Optional Information

Contract/Grant/Project number
W-7405-ENG-48
Notes
PDF-FILE: 6 ; SIZE: 1.6 MBYTES
Funding organization
US Department of Energy (United States)