Published 1986 | Version v1
Book Metadata-only

Reduced acetylcholine synthesis in Alzheimer's disease is a clinically relevant change

Creators

  • 1. Institute of Neurology, London

Description

This paper presents a study of patients in the presenium. Psychological assessment was carried out to provide measures of relative severity of dementia, with which pathological and chemical indices of impairment could be compared. Fresh cortical biopsy tissue permitted the assay of ChAT activity, and also the determination of acetylcholine synthesis in a preparation enriched in cortical synaptosomes. Additionally, choline uptake has been measured for comparison. Nuerosurgical samples from all patients were handled and processed for measuring acetylcholine synthesis by incorporation of U-14C-glucoase into C 14-acetylcholine in neocortical tissue prisms. Cortical sections from most of the patients were found on light microscopy to contain the characteristic changes of Alzheimer's disease

Additional details

Publishing Information

Publisher
Plenum Press.
Imprint Place
New York, NY (USA)
Imprint Title
Dynamics of cholinergic functions
Journal Page Range
p. 111-121.

Conference

Title
Conference on dynamics of cholinergic function.
Dates
31 Oct - 4 Nov 1983.
Place
Ogle Bay Park, WV (USA).

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
18056510
Subject category
S60: APPLIED LIFE SCIENCES;
Resource subtype / Literary indicator
Conference
Descriptors DEI
ACETYLCHOLINE; BEHAVIOR; BIOSYNTHESIS; CARBON 14 COMPOUNDS; CEREBRAL CORTEX; CHOLINE; CHOLINESTERASE; ENZYME ACTIVITY; NERVE CELLS; NERVOUS SYSTEM DISEASES; O-GLYCOSYL HYDROLASES; PATHOLOGICAL CHANGES; PATIENTS; RADIOENZYMATIC ASSAY; TISSUE EXTRACTS; UPTAKE
Descriptors DEC
ALCOHOLS; AMINES; ANIMAL CELLS; AUTONOMIC NERVOUS SYSTEM AGENT; BIOLOGICAL MATERIALS; BODY; BRAIN; CARBON COMPOUNDS; CARBOXYLESTERASES; CENTRAL NERVOUS SYSTEM; CEREBRUM; DISEASES; DRUGS; ENZYMES; ESTERASES; ESTERS; GLYCOSYL HYDROLASES; HYDROLASES; HYDROXY COMPOUNDS; LIPOTROPIC FACTORS; MATERIALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PARASYMPATHOMIMETICS; QUATERNARY COMPOUNDS; SOMATIC CELLS; SYNTHESIS