Published May 2021 | Version v1
Journal article Metadata-only

MicroPET imaging of vesicular monoamine transporter 2 revealed the potentiation of (+)-dihydrotetrabenazine on MPTP-induced degeneration of dopaminergic neurons

Creators

  • 1. Department of Radiopharmaceuticals, School of Pharmacy, Nanjing Medical University, Nanjing 211166 (China)
  • 2. NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, Jiangsu 214063 (China)

Description

Vesicular monoamine transporter 2 (VMAT2) has been associated with the risk of PD. Genetic reduction of VMAT2 level is reported to increase the vulnerability for dopaminergic neurodegeneration. In this study, by using in vivo microPET imaging with a VMAT2 radioligand [18F]fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-DTBZ), we investigated the enhanced role of inhibiting VMAT2 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced loss of dopaminergic neurons.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2021.02.004

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2021.02.004;
PII
S0969805121000317;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
96
Journal Page Range
p. 9-18
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
53120617
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
FLUORINE 18; GENETICS; HAZARDS; IN VIVO; NERVE CELLS; NERVOUS SYSTEM DISEASES; VULNERABILITY
Descriptors DEC
ANIMAL CELLS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGY; DISEASES; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; RADIOISOTOPES; SOMATIC CELLS

Optional Information

Copyright
Copyright (c) 2021 Elsevier Inc. All rights reserved.