Synthesis of water-dispersed magnetic nanoparticles (H₂O-DMNPs) of β-cyclodextrin modified Fe₃O₄ and its catalytic application in Kabachnik–Fields multicomponent reaction

Water-dispersed magnetic nanoparticles (H₂O-DMNPs) of β-cyclodextrin modified Fe₃O₄ were successfully synthesized. β-Cyclodextrin acts as stabilizer and structure directing agent of Fe₃O₄. Subsequently, the dispersion of Fe₃O₄@β-CD was applied for the Kabachnik–Fields multicomponent reaction through three-component synthesis of an amine, aldehyde, and dimethylphosphonate. β-CD had also a drastic effect in accelerating the catalysis of phosphonate synthesis. By this protocol, phosphonate derivatives were synthesized in high yields and the catalyst was recycled for 10 successful runs. - Highlights: • Fe₃O₄@β-CD as a nanomagnetically catalyst. • A reusable magnetic nanocatalyst synthesis using commercially available compounds. • Represents advantages, operational simplicity, no waste, higher yield and with easy workup