Published September 2020
| Version v1
Journal article
Design, synthesis, and biological evaluation of chalcone-linked thiazole-imidazopyridine derivatives as anticancer agents
Creators
- 1. Government Degree and PG College. Department of Chemistry (India)
- 2. GITAM Institute of Science Gandhi Institute of Technology and Management - Deemed to be University. Department of Chemistry (India)
- 3. University College of Engineering (Autonomous), Jawaharlal Nehru Technological University. Department of Chemistry (India)
- 4. Krishna University. Department of Chemistry (India)
- 5. SR and BGNR Govt. Arts and Science College (Autonomous). Department of Chemistry (India)
- 6. Maharishi Arvind College of Pharmacy. Department of Pharmaceutical Chemistry (India)
- 7. Vishnu Institute of Pharmaceutical Education & Research (VIPER) (India)
Description
A novel library of chalcone linked thiazole-imidazopyridine (12a–j) derivatives were designed, synthesized, and their structures were characterized by 1H NMR, 13C NMR and mass spectral studies. Further, all compounds were tested for their anticancer effects on four human cancer cell lines including MCF-7 (breast carcinoma), A549 (lung carcinoma), DU-145 (prostate carcinoma) and MDA MB-231 (breast carcinoma) by employing MTT method, using etoposide as the positive control. Among them, compound 12b displayed more potent anticancer activity against four cancer cell lines when compared to the positive control.
Additional details
Identifiers
Publishing Information
- Journal Title
- Medicinal Chemistry Research (Print)
- Journal Volume
- 29
- Journal Issue
- 9
- Journal Page Range
- p. 1643-1654
- ISSN
- 1054-2523
INIS
- Country of Publication
- United States
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 55088378
- Subject category
- S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; S60: APPLIED LIFE SCIENCES; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BENZIMIDAZOLES; BIOSYNTHESIS; CARBON 13; CELL CULTURES; CHALCOGENIDES; CHEMICAL SHIFT; EVALUATION; HYDROGEN 1; LUNGS; MAMMARY GLANDS; MASS SPECTRA; NUCLEAR MAGNETIC RESONANCE; PROSTATE; THIAZOLES; TRIAZOLES; TUMOR CELLS
- Descriptors DEC
- ANIMAL CELLS; AZOLES; BODY; CARBON ISOTOPES; EVEN-ODD NUCLEI; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROGEN ISOTOPES; IMIDAZOLES; ISOTOPES; LIGHT NUCLEI; MAGNETIC RESONANCE; MALE GENITALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; RESONANCE; RESPIRATORY SYSTEM; SPECTRA; STABLE ISOTOPES; SYNTHESIS
Optional Information
- Copyright
- Copyright (c) 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020