Interaction of toxic effect of the organophosphorus pesticide cyolane and schistosoma mansoni infection in male albino mice

The organophosphorus (OP) insecticides are the most widely used substances employed in agriculture and pollute the environment. On the other hand, schistosomiasis is still a serious public health problem in Egypt. The present study was performed to investigate the toxic interaction of the OP insecticide cyolane and Schistosoma mansoni infection on the liver and kidney functions, blood glucose and insulin hormone in male albino mice. The obtained data indicated that treatment of normal mice or those infected by S.mansoni with cyolane at daily dose levels of 1/50 or 1/20 LD 50 significantly increased AST, ALT, total and direct bilirubin, urea and creatinine. Also, fluctuations in fasting glucose levels and in insulin hormone were recorded in cyolane treated groups. These fluctuations were pronounced in infected - treated groups. Histopathological investigation revealed that, hepatic tissue sections in S. mansoni infected group showed both cellular and fibrocellular granuloma around ova. In S. mansoni infected group and treated with cyolane, the mean number of granuloma was decreased. The granulomas were fibrocellular rather than cellular. The foci of the inflammatory cells detected in hepatic parenchyma without ova were characteristic in infected - treated groups. Consequently, exposure to insecticides should be avoided specially in the rural areas where schistosomiasis is still endemic