Published July 22, 2009 | Version v1
Journal article Metadata-only

pH-sensitive intracellular photoluminescence of carbon nanotube-fluorescein conjugates in human ovarian cancer cells

Creators

  • 1. Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089 (United States)
  • 2. Department of Chemistry, University of Southern California, Los Angeles, CA 90089 (United States)
  • 3. Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, CA 90089 (United States)

Description

To add to the understanding of the properties of functionalized carbon nanotubes in biological applications, we report a monotonic pH sensitivity of the intracellular fluorescence emission of single-walled carbon nanotube-fluorescein carbazide (SWCNT-FC) conjugates in human ovarian cancer cells. Light-stimulated intracellular hydrolysis of the amide linkage and localized intracellular pH changes are proposed as mechanisms. SWCNT-FC conjugates may serve as intracellular pH sensors.

Availability note (English)

Available from http://dx.doi.org/10.1088/0957-4484/20/29/295101

Additional details

Identifiers

DOI
10.1088/0957-4484/20/29/295101;
PII
S0957-4484(09)14855-9;

Publishing Information

Journal Title
Nanotechnology (Print)
Journal Volume
20
Journal Issue
29
Journal Page Range
[7 p.]
ISSN
0957-4484

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
42071610
Subject category
S77: NANOSCIENCE AND NANOTECHNOLOGY;
Descriptors DEI
CARBON; FLUORESCEIN; FLUORESCENCE; HYDROLYSIS; NANOTUBES; NEOPLASMS; PH VALUE; PHOTOLUMINESCENCE; SENSITIVITY; SENSORS
Descriptors DEC
AROMATICS; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DECOMPOSITION; DISEASES; DYES; ELEMENTS; EMISSION; HYDROXY ACIDS; HYDROXY COMPOUNDS; LUMINESCENCE; LYSIS; NANOSTRUCTURES; NONMETALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; PHENOLS; PHOTON EMISSION; POLYPHENOLS; SOLVOLYSIS