Comparative study of the influence of radioactive seeds implantation and radiotherapy on cytokine of VX₂ tumor rabbits

Objective: To discuss the influence of radioactive seeds implantation and radiotherapy on VX₂ tumor cytokine. Methods: 60 male New Zealand White rabbits were randomly divided into 3 groups, 20 for radioactive seeds implantation group, 20 for radiotherapy group, and 20 for control group. After 12 d the implantation with the VX₂ soft tumor, radioactive seeds implantation and radiotherapy were performed separately, the control group underwent no therapy. IL-2, IL-6, IL-8, TNF and IGF were measured. Results: The survival periods of experimental group were 15 d longer than the control group. The concentration of IL-2, IL-8 in serum decreased gradually, the decreasing extent control>radiotherapy>radioactive seeds implantation; the concentration of IL-6, IGF raised gradually, rising extent control>radiotherapy>radioactive seeds implantation. Conclusions: The immune system of rabbits with VX₂ tumor were suppressed, there is little influence of radioactive seeds implantation and radiotherapy on cytokine. Radioactive seeds implantation and radiotherapy are effective methods to treat VX₂ tumor. (authors)