Published July 1982 | Version v1
Journal article Metadata-only

A simple and fast method in testing a radiosensitizer in vivo by the study of hair dysplasia in the young mouse

Creators

  • 1. Laboratoire de Radiobiologie, Liege (Belgium)

Description

The study of radiation induced hair dysplasia in 8 day old mice allows investigations of the radiosensitizing power of a drug as early as the third day after irradiation without complicated equipment. The results being quantitative, they allow easy determination of the ER of a drug. In this study the method was applied to the action of metronidazol under anoxia

Abstract (French)

L'etude de la dysplasie pilaire radio-induite chez le souriceau age de 8 jours permet de rechercher le pouvoir radiosensibilisant d'une drogue des le troisieme jour apres l'irradiation, sans appareillage complique. Les resultats etant quantitatifs, ils permettent de determiner facilement le FA de la drogue. La methode est appliquee dans ce travail a l'action du metronidazole sous anoxie

Additional details

Additional titles

Original title (French)
Methode simple et rapide de la recherche du pouvoir radiosensibilisant d'une drogue in vivo par l'etude de la dysplasie pilaire chez le souriceau

Publishing Information

Journal Title
C. R. Seances Soc. Biol. Fil.
Journal Volume
176
Journal Issue
3
Series
C. R. Seances Soc. Biol. Fil.
Journal Page Range
420-421
ISSN
0037-9026

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
14717265
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; GAMMA RADIATION; HAIR; METRONIDAZOLE; MICE; RADIOSENSITIVITY; WHOLE-BODY IRRADIATION
Descriptors DEC
ALCOHOLS; ANIMALS; AZOLES; BIOLOGICAL EFFECTS; BODY; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; NITRO COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIATIONS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; RODENTS; SKIN; VERTEBRATES