Skeletal distribution and biochemical parameters of Paget's disease
Creators
- 1. Faculte Alexis Carrel, Lyon, France
Description
Quantitative bone scans were performed with /sup 99m/Tc-EHDP in 170 untreated pagetic patients (93 men, 77 women; mean age, 65.4 years). The distribution of 863 pagetic skeletal locations was analyzed. Bone scans demonstrated 8.3% more pagetic sites than roentgenograms. The extent of Paget's disease was evaluated in each patient by a scintigraphic skeletal index. This index correlated with serum alkaline phosphatase (SAP) and urinary hydroxyproline (HyPro) levels, and also with hypocalcemic acute response to calcitonin. The correlation of SAP with an index of activity (extent index adjusted by uptake ratios) was better than with the nonadjusted index. Only 30.6% of pagetic sites were responsible for clinical symptoms. No correlation was found between age and skeletal index of the disease
Additional details
Publishing Information
- Journal Title
- Clin. Orthop. Relat. Res.
- Journal Issue
- no.217
- Series
- Clin. Orthop. Relat. Res.
- ISSN
- 0009-921X
- CODEN
- CORTB
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 18079997
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- ALKALINE PHOSPHATASE; ANTIBODIES; BIOMEDICAL RADIOGRAPHY; CALCITONIN; COMPARATIVE EVALUATIONS; DIAGNOSIS; HYDROXYPROLINE; ISOMERIC NUCLEI; PATIENTS; SCINTISCANNING; SKELETAL DISEASES; SKELETON; TECHNETIUM 99
- Descriptors DEC
- AMINES; AMINO ACIDS; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACIDS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; ENZYMES; ESTERASES; EVALUATION; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; HORMONES; HOURS LIVING RADIOISOTOPES; HYDROLASES; HYDROXY ACIDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; PHOSPHATASES; POLYPEPTIDES; PROTEINS; PYRROLES; PYRROLIDINES; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; YEARS LIVING RADIOISOTOPES