Blood and urine β2-microglobulin in pyelonephritic patients with diabetes mellituS

Blood and wine β2-microglobulin (B2 MG) was determined in pyelonephritic patients with diabetes mellitus using the radioimmunoassay method. Different lesions of urogenital system such as pyelonephrit in 27 cases, isolated nephro microangiopathy in 25 cases, Urinary tracks infection in 13 cases Were revealed on the base of a complex examination (radioisotopic renography, dynamic nephroscintigraphy, extretory urography etc). No pathologic changes were discovered in 12 patients. It has been shown that simultaneous determination of blood and wine β2-MG allows one to specify a place of primary nephron damage. An increase of β2-MG concentration in blood serum is characteristic for violation of glomenular function of kidneys but an increase of its excretion with urine indicates a damage of proximal small channels