Mathematical modelling of pharmacokinetics dates

The objective of the present work is to evaluate as much the type as the consideration algorithm in the estimate of the pharmacokinetics parameters after the administration of a intravenous dose of the synthetic peptide 99 Tc labelled X300 in the rat. The plasmatic data have been adjusted to a bicompartmental model after intravenous administration with one elimination of first order by means of non lineal regression (for we have used it the one computer packages WinNonlin v2.1). The estimate of the pharmacokinetics parameters have been carried out giving the same specific weight to each experimental value (that is to say, without pondering) or using 1/Y as consideration schema . This consideration factor is the one that should be used when the experimental values follow a distribution of Poisson, like it happens when the numeric value of the plasmatic concentration to a time certain drift of a radioactive measure. The results show that the consideration with the factor 1/Y are adapted in this type of studies